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1996-02-27
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Document 0696
DOCN M9630696
TI Drug induced acute pancreatitis: incidence and severity.
DT 9603
AU Lankisch PG; Droge M; Gottesleben F; Department of Internal Medicine,
Municipal Hospital of Luneburg,; Germany.
SO Gut. 1995 Oct;37(4):565-7. Unique Identifier : AIDSLINE MED/96097888
AB To determine the incidence and severity of drug induced acute
pancreatitis, data from 45 German centres of gastroenterology were
evaluated. Among 1613 patients treated for acute pancreatitis in 1993,
drug induced acute pancreatitis was diagnosed in 22 patients (incidence
1.4%). Drugs held responsible were azathioprine,
mesalazine/sulfasalazine, 2',3'-dideoxyinosine (ddI), oestrogens,
frusemide, hydrochlorothiazide, and rifampicin. Pancreatic necrosis not
exceeding 33% of the organ was found on ultrasonography or computed
tomography, or both, in three patients (14%). Pancreatic pseudocysts did
not occur. A decrease of arterial PO2 reflecting respiratory
insufficiency, and an increase of serum creatinine, reflecting renal
insufficiency as complications of acute pancreatitis were seen in two
(9%) and four (18%) patients, respectively. Artificial ventilation was
not needed, and dialysis was necessary in only one (5%) case. Two
patients (9%) died of AIDS and tuberculosis, respectively; pancreatitis
did not seem to have contributed materially to their death. In
conclusion, drugs rarely cause acute pancreatitis, and drug induced
acute pancreatitis usually runs a benign course.
DE Acute Disease Adult Aged Aged, 80 and over Azathioprine/ADVERSE
EFFECTS Didanosine/ADVERSE EFFECTS Estrogens/ADVERSE EFFECTS Female
Furosemide/ADVERSE EFFECTS Germany/EPIDEMIOLOGY Human
Hydrochlorothiazide/ADVERSE EFFECTS Incidence Length of Stay Male
Middle Age Pancreatitis/*CHEMICALLY INDUCED/EPIDEMIOLOGY
Rifampin/ADVERSE EFFECTS Sulfasalazine/ADVERSE EFFECTS JOURNAL ARTICLE
MULTICENTER STUDY
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).